Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.
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ABSTRACT:
SUBMITTER: Sotillo R
PROVIDER: S-EPMC1850996 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Publications
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.
Sotillo Rocío R Hernando Eva E Díaz-Rodríguez Elena E Teruya-Feldstein Julie J Cordón-Cardo Carlos C Lowe Scott W SW Benezra Robert R
Cancer cell 20061228 1
Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of broken chromosomes, anaphase bridges, and whole-chromosome gains and losses, as well as acceleration of myc-induced lymphomagenesis. Moreover, continued overexpression of Mad2 is not required for tumo ...[more]
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