Ontology highlight
ABSTRACT:
SUBMITTER: Sosinsky A
PROVIDER: S-EPMC1851073 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Sosinsky Alona A Honig Barry B Mann Richard S RS Califano Andrea A
Proceedings of the National Academy of Sciences of the United States of America 20070329 15
The functional annotation of the nonprotein-coding DNA of eukaryotic genomes is a problem of central importance. Phylogenetic footprinting methods, which attempt to identify functional regulatory regions by comparing orthologous genomic sequences of evolutionarily related species, have shown promising results. The main advantage of this class of approaches is that they do not require any knowledge of the regulating transcription factors. Here we describe a method called Enhancer Detection using ...[more]