Tissue-specific inactivation of murine M6P/IGF2R.
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ABSTRACT:
SUBMITTER: Wylie AA
PROVIDER: S-EPMC1851115 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Publications
Tissue-specific inactivation of murine M6P/IGF2R.
Wylie Andrew A AA Pulford David J DJ McVie-Wylie Alison J AJ Waterland Robert A RA Evans Heather K HK Chen Yuan-Tsong YT Nolan Catherine M CM Orton Terry C TC Jirtle Randy L RL
The American journal of pathology 20030101 1
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity. M6P/IGF2R is an imprinted gene in mice with expression only from the maternal allele. Complete knockout of this gene causes neonatal lethality, thus preventing analysis of its multifunctional role postnatally. To help elucidate the biological functions of M6P/IGF2R in adulthood, ...[more]
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