Ontology highlight
ABSTRACT:
SUBMITTER: Mizushima T
PROVIDER: S-EPMC1851568 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Mizushima Tsunehiro T Yoshida Yukiko Y Kumanomidou Taichi T Hasegawa Yuko Y Suzuki Atsuo A Yamane Takashi T Tanaka Keiji K
Proceedings of the National Academy of Sciences of the United States of America 20070326 14
The ubiquitin ligase complex SCF(Fbs1), which contributes to the ubiquitination of glycoproteins, is involved in the endoplasmic reticulum-associated degradation pathway. In SCF ubiquitin ligases, a diverse array of F-box proteins confers substrate specificity. Fbs1/Fbx2, a member of the F-box protein family, recognizes high-mannose oligosaccharides. To elucidate the structural basis of SCF(Fbs1) function, we determined the crystal structures of the Skp1-Fbs1 complex and the sugar-binding domain ...[more]