Ontology highlight
ABSTRACT:
SUBMITTER: Ghazi A
PROVIDER: S-EPMC1851597 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Ghazi Arjumand A Henis-Korenblit Sivan S Kenyon Cynthia C
Proceedings of the National Academy of Sciences of the United States of America 20070328 14
The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are required for the extended lifespan of Caenorhabditis elegans insulin/insulin-like growth factor-1-sig ...[more]