Ontology highlight
ABSTRACT:
SUBMITTER: Deane JA
PROVIDER: S-EPMC1852227 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Deane Jonathan A JA Kharas Michael G MG Oak Jean S JS Stiles Linda N LN Luo Ji J Moore Travis I TI Ji Hong H Rommel Christian C Cantley Lewis C LC Lane Thomas E TE Fruman David A DA
Blood 20070401 7
The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here we analyze conditional mutant mice in which thymocytes and T cells lack the major class IA regulatory subunits p85alpha, p55alpha, p50alpha, and p85beta. These cells exhibit nearly c ...[more]