Ontology highlight
ABSTRACT:
SUBMITTER: Ling C
PROVIDER: S-EPMC1852792 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20070329 8
The Fanconi anemia (FA) core complex plays a central role in the DNA damage response network involving breast cancer susceptibility gene products, BRCA1 and BRCA2. The complex consists of eight FA proteins, including a ubiquitin ligase (FANCL) and a DNA translocase (FANCM), and is essential for monoubiquitination of FANCD2 in response to DNA damage. Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and directly interacts w ...[more]