Ontology highlight
ABSTRACT:
SUBMITTER: Vecerek B
PROVIDER: S-EPMC1852835 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Vecerek Branislav B Moll Isabella I Bläsi Udo U
The EMBO journal 20070201 4
The Fe2+-dependent Fur protein serves as a negative regulator of iron uptake in bacteria. As only metallo-Fur acts as an autogeneous repressor, Fe2+scarcity would direct fur expression when continued supply is not obviously required. We show that in Escherichia coli post-transcriptional regulatory mechanisms ensure that Fur synthesis remains steady in iron limitation. Our studies revealed that fur translation is coupled to that of an upstream open reading frame (uof), translation of which is dow ...[more]