Ontology highlight
ABSTRACT:
SUBMITTER: Yuan H
PROVIDER: S-EPMC1853296 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20070117 6
Low brain levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) lead to convulsions. Inhibition of GABA aminotransferase increases the concentration of GABA and can terminate the convulsions. Earlier we reported the synthesis of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid (2), which is 186 times more potent an inactivator of GABA aminotransferase than the epilepsy drug S-vigabatrin. The corresponding dichloromethylene analogue of 2 (compound 3) has been made ...[more]