Ontology highlight
ABSTRACT:
SUBMITTER: Gerth ML
PROVIDER: S-EPMC1853344 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20070123 3
Human thymidine kinase 2 (TK2) is critical for the nucleotide salvage pathway and phosphorylation of nucleoside analog prodrugs in vivo; however, it remains poorly studied because of difficulties in expressing it heterologously. TK2 is strictly pyrimidine-specific, whereas its phylogenetic relative, the Drosophila melanogaster deoxyribonucleoside kinase (DmdNK), shows higher activity and broader specificity towards both pyrimidines and purines. These differences are counterintuitive, as only two ...[more]