Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.
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ABSTRACT:
SUBMITTER: Wu B
PROVIDER: S-EPMC1855210 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.
Wu Beibei B Crampton Steve P SP Hughes Christopher C W CC
Immunity 20070201 2
Wnts are a family of secreted glycoproteins with diverse developmental roles, including regulation of cell migration; however, little is known about wnt signaling in mature T cells. We find that endothelial-cell-derived wnts, acting through Frizzled receptors, induce matrix metalloproteinase (MMP) 2 and MMP9 expression in effector T cells. Blocking wnt signaling, or MMP activity, reduces T cell migration through the basement membrane in vitro and into inflamed skin in vivo. Wnt signaling stabili ...[more]
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