Ontology highlight
ABSTRACT:
SUBMITTER: Steinmetz MO
PROVIDER: S-EPMC1855353 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Steinmetz Michel O MO Jelesarov Ilian I Matousek William M WM Honnappa Srinivas S Jahnke Wolfgang W Missimer John H JH Frank Sabine S Alexandrescu Andrei T AT Kammerer Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20070416 17
Coiled coils have attracted considerable interest as design templates in a wide range of applications. Successful coiled-coil design strategies therefore require a detailed understanding of coiled-coil folding. One common feature shared by coiled coils is the presence of a short autonomous helical folding unit, termed "trigger sequence," that is indispensable for folding. Detailed knowledge of trigger sequences at the molecular level is thus key to a general understanding of coiled-coil formatio ...[more]