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Heterologous production of albicidin: a promising approach to overproducing and characterizing this potent inhibitor of DNA gyrase.

ABSTRACT: The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.

SUBMITTER: Vivien E 

PROVIDER: S-EPMC1855474 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature

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Heterologous production of albicidin: a promising approach to overproducing and characterizing this potent inhibitor of DNA gyrase.

Vivien Eric E   Pitorre Delphine D   Cociancich Stéphane S   Pieretti Isabelle I   Gabriel Dean W DW   Rott Philippe C PC   Royer Monique M  

Antimicrobial agents and chemotherapy 20070112 4

The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction. ...[more]

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