Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435.
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ABSTRACT:
SUBMITTER: Watanabe S
PROVIDER: S-EPMC1855803 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
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Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435.
Watanabe Shinya S Ito Teruyo T Morimoto Yuh Y Takeuchi Fumihiko F Hiramatsu Keiichi K
Journal of bacteriology 20070119 7
Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 to 320 kbp) were found to accompany spontaneous loss of beta-lactam resistance during drug-free passage of the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing of the rearranged chromosomal loci revealed that ISSha1 of S. haemolyticus is responsible for the chromosome rearrangements. ...[more]
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