Comparative analysis of hmuO function and expression in Corynebacterium species.
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ABSTRACT:
SUBMITTER: Kunkle CA
PROVIDER: S-EPMC1855885 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Comparative analysis of hmuO function and expression in Corynebacterium species.
Kunkle Carey A CA Schmitt Michael P MP
Journal of bacteriology 20070223 9
We have constructed defined deletions in the hmuO gene from Corynebacterium diphtheriae and Corynebacterium ulcerans and show that the C. ulcerans hmuO mutation results in a significant reduction in hemoglobin-iron utilization, whereas in C. diphtheriae strains, deletion of hmuO caused no or only partial reduction in the utilization of heme as an iron source. We also show that expression from the C. ulcerans hmuO promoter exhibits minimal regulation by iron and heme whereas transcription from th ...[more]
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