Ontology highlight
ABSTRACT:
SUBMITTER: Saxe MD
PROVIDER: S-EPMC1859958 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Saxe Michael D MD Battaglia Fortunato F Wang Jing-Wen JW Malleret Gael G David Denis J DJ Monckton James E JE Garcia A Denise R AD Sofroniew Michael V MV Kandel Eric R ER Santarelli Luca L Hen René R Drew Michael R MR
Proceedings of the National Academy of Sciences of the United States of America 20061106 46
Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavioral deficit and a loss of synaptic plasticity within the dentate gyrus. Specifically, focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural pro ...[more]