Unknown

Dataset Information

0

Expression of calcitonin receptor-like receptor in human vascular tumours.


ABSTRACT: BACKGROUND: Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis. AIM: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours. METHODS: CRLR expression was investigated in several specimens of Kaposi's sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction. RESULTS: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium. CONCLUSIONS: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.

SUBMITTER: Hagner S 

PROVIDER: S-EPMC1861761 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Expression of calcitonin receptor-like receptor in human vascular tumours.

Hagner S S   Stahl U U   Grimm T T   Stürzl M M   Lang R E RE  

Journal of clinical pathology 20061001 10


<h4>Background</h4>Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.<h4>Aim</h4>To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.<h4>Methods</h4>CRLR  ...[more]

Similar Datasets

| S-EPMC5600720 | biostudies-literature
| S-EPMC3958426 | biostudies-literature
| S-EPMC8776895 | biostudies-literature
| S-EPMC9962437 | biostudies-literature
| S-EPMC6379965 | biostudies-literature
| S-EPMC1770303 | biostudies-literature
| S-EPMC7988903 | biostudies-literature
| S-EPMC2360705 | biostudies-literature
| S-EPMC3415637 | biostudies-literature
| S-EPMC4775073 | biostudies-literature