Simplified detection of microsatellite instability in colorectal cancer without the need for corresponding germline DNA analysis.
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ABSTRACT:
SUBMITTER: Ebinger M
PROVIDER: S-EPMC1861765 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Simplified detection of microsatellite instability in colorectal cancer without the need for corresponding germline DNA analysis.
Ebinger M M Sotlar K K Weber A A Bock C T CT Bültmann B D BD Kandolf R R
Journal of clinical pathology 20061001 10
A panel of five quasimonomorphic mononucleotide repeats that dispenses with the need to analyse corresponding germline DNA was proposed by Suraweera et al for the detection of high-frequency microsatellite instability (MSI) in colorectal cancer. Using this panel, a simplified and a more sensitive (compared with the original) algorithm (p<0.05) was developed to define the instability of each repeat by assessing the morphological shape of its plot and not its absolute length. 103 cases of colorect ...[more]
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