Ontology highlight
ABSTRACT:
SUBMITTER: Cambras T
PROVIDER: S-EPMC1863469 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Cambras Trinitat T Weller John R JR Anglès-Pujoràs Montserrat M Lee Michael L ML Christopher Andrea A Díez-Noguera Antoni A Krueger James M JM de la Iglesia Horacio O HO
Proceedings of the National Academy of Sciences of the United States of America 20070423 18
Proper functioning of the human circadian timing system is crucial to physical and mental health. Much of what we know about this system is based on experimental protocols that induce the desynchronization of behavioral and physiological rhythms within individual subjects, but the neural (or extraneural) substrates for such desynchronization are unknown. We have developed an animal model of human internal desynchrony in which rats are exposed to artificially short (22-h) light-dark cycles. Under ...[more]