Ontology highlight
ABSTRACT:
SUBMITTER: Lukacik P
PROVIDER: S-EPMC1863559 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Lukacik Petra P Keller Brigitte B Bunkoczi Gabor G Kavanagh Kathryn L KL Lee Wen Hwa WH Adamski Jerzy J Oppermann Udo U
The Biochemical journal 20070301 3
To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17beta-HSD (17beta-hydroxysteroid dehydrogenase) activity. 17beta-HSD enzymes are primarily involved in the metabolism of steroids at the C-17 position and also of other substrates such as fatty acids, prostaglandins and xenobiotics. In vitro, DHRS10 converts NA ...[more]