Ontology highlight
ABSTRACT:
SUBMITTER: Riedel T
PROVIDER: S-EPMC1864831 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Riedel T T Lozinsky I I Schmalzing G G Markwardt F F
Biophysical journal 20061222 7
Human P2X7 receptors were expressed in Xenopus laevis oocytes and single channels were recorded using the patch-clamp technique in the outside-out configuration. ATP4- evoked two types of P2X7 receptor-mediated single channel currents characterized by short-lived and long-lived openings. The short- and long-lasting open states had mean open times of approximately 5 and approximately 20 ms and slope conductances near -60 mV of 9 and 13 pS, respectively. The open probabilities of the short and lon ...[more]