Ontology highlight
ABSTRACT:
SUBMITTER: Garczynski SF
PROVIDER: S-EPMC1864938 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Garczynski Stephen F SF Crim Joe W JW Brown Mark R MR
Peptides 20061130 1
A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by transfected cells, suggesting sNPFR acts via G(i/o). Transcripts for sNPF and sNPFR were present in all body regions of larvae, pupae, and adults, and immunoblots for sNPFR confirme ...[more]