The oligomeric structure of high molecular weight adiponectin.
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ABSTRACT:
SUBMITTER: Suzuki S
PROVIDER: S-EPMC1865574 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Publications
The oligomeric structure of high molecular weight adiponectin.
Suzuki Shinji S Wilson-Kubalek Elizabeth M EM Wert David D Tsao Tsu-Shuen TS Lee David H DH
FEBS letters 20070130 5
There is great interest in the structure of adiponectin as its oligomeric state may specify its biological activities. It occurs as a trimer, a hexamer and a high molecular weight complex. Epidemiological data indicate that the high molecular weight form is significant with low serum levels in type 2 diabetics but to date, has not been well-defined. To resolve this issue, characterization of this oligomer from bovine serum and 3T3-L1 adipocytes by sedimentation equilibrium centrifugation and gel ...[more]
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