Ontology highlight
ABSTRACT:
SUBMITTER: Stern S
PROVIDER: S-EPMC1865588 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Stern Shay S Dror Tali T Stolovicki Elad E Brenner Naama N Braun Erez E
Molecular systems biology 20070424
Cells adjust their transcriptional state to accommodate environmental and genetic perturbations. An open question is to what extent transcriptional response to perturbations has been specifically selected along evolution. To test the possibility that transcriptional reprogramming does not need to be 'pre-designed' to lead to an adaptive metabolic state on physiological timescales, we confronted yeast cells with a novel challenge they had not previously encountered. We rewired the genome by recru ...[more]