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T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.


ABSTRACT: Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.

SUBMITTER: Iwai LK 

PROVIDER: S-EPMC1865602 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature

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T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.

Iwai Leo Kei LK   Yoshida Márcia M   Sadahiro Aya A   da Silva Washington Robert WR   Marin Maria Lucia ML   Goldberg Anna Carla AC   Juliano Maria Aparecida MA   Juliano Luiz L   Shikanai-Yasuda Maria Aparecida MA   Kalil Jorge J   Cunha-Neto Edecio E   Travassos Luiz R LR  

Clinical and vaccine immunology : CVI 20070228 4


Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM. ...[more]

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