Ontology highlight
ABSTRACT:
SUBMITTER: Mueller SM
PROVIDER: S-EPMC1866003 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Mueller Sandra M SM Schaetz Birgit B Eismann Kathrin K Bergmann Silke S Bauerle Michael M Schmitt-Haendle Matthias M Walter Hauke H Schmidt Barbara B Korn Klaus K Sticht Heinrich H Spriewald Bernd B Harrer Ellen G EG Harrer Thomas T
Journal of virology 20070103 6
To determine the influence of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells on the development of drug resistance mutations in the HIV-1 protease, we analyzed protease sequences from viruses from a human leukocyte antigen class I (HLA class I)-typed cohort of 94 HIV-1-positive individuals. In univariate statistical analyses (Fisher's exact test), minor and major drug resistance mutations as well as drug-associated polymorphisms showed associations with HLA class I alleles. Al ...[more]