Ontology highlight
ABSTRACT:
SUBMITTER: Toyoda A
PROVIDER: S-EPMC186650 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Toyoda Atsushi A Noguchi Hideki H Taylor Todd D TD Ito Takehiko T Pletcher Mathew T MT Sakaki Yoshiyuki Y Reeves Roger H RH Hattori Masahira M
Genome research 20020901 9
Comprehensive knowledge of the gene content of human chromosome 21 (HSA21) is essential for understanding the etiology of Down syndrome (DS). Here we report the largest comparison of finished mouse and human sequence to date for a 1.35-Mb region of mouse chromosome 16 (MMU16) that corresponds to human chromosome 21q22.2. This includes a portion of the commonly described "DS critical region," thought to contain a gene or genes whose dosage imbalance contributes to a number of phenotypes associate ...[more]