Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association.
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ABSTRACT:
SUBMITTER: Rosenberger A
PROVIDER: S-EPMC1866728 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
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Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association.
Rosenberger Albert A Janicke Nico N Köhler Karola K Korb Katrin K Kulle Bettina B Bickeböller Heike H
BMC genetics 20051230
For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quanti ...[more]
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