Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines.
Ontology highlight
ABSTRACT:
SUBMITTER: Togashi Y
PROVIDER: S-EPMC1868896 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines.
Togashi Yuichi Y Mikhailov Alexander S AS
Proceedings of the National Academy of Sciences of the United States of America 20070516 21
Analyzing nonlinear conformational relaxation dynamics in elastic networks corresponding to two classical motor proteins, we find that they respond by well defined internal mechanical motions to various initial deformations and that these motions are robust against external perturbations. We show that this behavior is not characteristic for random elastic networks. However, special network architectures with such properties can be designed by evolutionary optimization methods. Using them, an exa ...[more]
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