Ontology highlight
ABSTRACT:
SUBMITTER: Vakonakis I
PROVIDER: S-EPMC1868906 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Vakonakis Ioannis I Staunton David D Rooney Luke M LM Campbell Iain D ID
The EMBO journal 20070426 10
The process by which fibronectin (FN), a soluble multidomain protein found in tissue fluids, forms insoluble fibrillar networks in the extracellular matrix is poorly understood. Cryptic sites found in FN type III domains have been hypothesized to function as nucleation points, thereby initiating fibrillogenesis. Exposure of these sites could occur upon tension-mediated mechanical rearrangement of type III domains. Here, we present the solution structures of the second type III domain of human FN ...[more]