Ontology highlight
ABSTRACT:
SUBMITTER: Di Maso V
PROVIDER: S-EPMC1869623 | biostudies-literature | 2007 Jan-Feb
REPOSITORIES: biostudies-literature
Di Maso Vittorio V Avellini Claudio C Crocè Lory Saveria LS Rosso Natalia N Quadrifoglio Franco F Cesaratto Laura L Codarin Erika E Bedogni Giorgio G Beltrami Carlo Alberto CA Tell Gianluca G Tiribelli Claudio C
Molecular medicine (Cambridge, Mass.) 20070101 1-2
APE1/Ref-1, normally localized in the nucleus, is a regulator of the cellular response to oxidative stress. Cytoplasmic localization has been observed in several tumors and correlates with a poor prognosis. Because no data are available on liver tumors, we investigated APE1/Ref-1 subcellular localization and its correlation with survival in 47 consecutive patients undergoing hepatocellular carcinoma (HCC) resection. APE1/Ref-1 expression was determined by immunohistochemistry in HCC and surround ...[more]