Ontology highlight
ABSTRACT:
SUBMITTER: de Oliveira T
PROVIDER: S-EPMC187406 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
de Oliveira Tulio T Engelbrecht Susan S Janse van Rensburg Estrelita E Gordon Michelle M Bishop Karen K zur Megede Jan J Barnett Susan W SW Cassol Sharon S
Journal of virology 20030901 17
Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1) subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To test this hypothesis, we examined the prevalences and patterns of cleavage site polymorphisms in the Gag, Gag-Pol, and Nef cleavage sites of C compared to those in non-C subtypes. Codon-based maximum-likelihood methods were used to assess the natural selection and evolutionary history of individual c ...[more]