Ontology highlight
ABSTRACT:
SUBMITTER: Niv MY
PROVIDER: S-EPMC1874628 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Niv Masha Y MY Ripoll Daniel R DR Vila Jorge A JA Liwo Adam A Vanamee Eva S ES Aggarwal Aneel K AK Weinstein Harel H Scheraga Harold A HA
Nucleic acids research 20070316 7
Type II restriction endonucleases (REases) are deoxyribonucleases that cleave DNA sequences with remarkable specificity. Type II REases are highly divergent in sequence as well as in topology, i.e. the connectivity of secondary structure elements. A widely held assumption is that a structural core of five beta-strands flanked by two alpha-helices is common to these enzymes. We introduce a systematic procedure to enumerate secondary structure elements in an unambiguous and reproducible way, and u ...[more]