Ontology highlight
ABSTRACT:
SUBMITTER: Kullmann M
PROVIDER: S-EPMC187493 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Kullmann Michael M Göpfert Ulrich U Siewe Basile B Hengst Ludger L
Genes & development 20021201 23
p27Kip1 restrains cell proliferation by binding to and inhibiting cyclin-dependent kinases. To investigate the mechanisms of p27 translational regulation, we isolated a complete p27 cDNA and identified an internal ribosomal entry site (IRES) located in its 5'UTR. The IRES allows for efficient p27 translation under conditions where cap-dependent translation is reduced. Searching for possible regulators of IRES activity we have identified the neuronal ELAV protein HuD as a specific binding factor ...[more]