SNPSTRs: empirically derived, rapidly typed, autosomal haplotypes for inference of population history and mutational processes.

ABSTRACT: Each independently evolving segment of the genomes of a sexually reproducing organism has a separate history reflecting part of the evolutionary history of that organism. Uniparentally or clonally inherited DNA segments such as the mitochondrial and chloroplast genomes and the nonrecombining portion of the Y chromosome have provided, to date, most of the known data regarding compound haplotypic variation within and among populations. These comparatively small segments include numerous polymorphic sites and undergo little or no recombination. Recombining autosomes, however, comprise the major repository of genetic variation. Technical challenges and recombination have limited large-scale application of autosomal haplotypes. We have overcome this barrier through development of a general appr

SUBMITTER: Mountain JL 

PROVIDER: S-EPMC187554 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature