Ontology highlight
ABSTRACT:
SUBMITTER: Ahn YM
PROVIDER: S-EPMC1876666 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Ahn Yu Mi YM Vogeti Lakshminarayana L Liu Chun-Jing CJ Santhapuram Hari K R HK White Jonathan M JM Vasandani Veena V Mitscher Lester A LA Lushington Gerald H GH Hanson Paul R PR Powell Douglas R DR Himes Richard H RH Roby Katherine F KF Ye Qizhuang Q Georg Gunda I GI
Bioorganic & medicinal chemistry 20061101 2
The design and synthesis of a small library of 8-amidoflavone, 8-sulfonamidoflavone, 8-amido-7-hydroxyflavone, and heterocyclic analogues of flavopiridol is reported. The potential activity of these compounds as kinase inhibitors was evaluated by cytotoxicity studies in MCF-7 and ID-8 cancer cell lines and inhibition of CDK2-Cyclin A enzyme activity in vitro. The antiproliferative and CDK2-Cyclin A inhibitory activity of these analogues was significantly lower than the activity of flavopiridol. ...[more]