Unknown

Dataset Information

0

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.


ABSTRACT: Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the "bully" whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion in the third exon of MSTN leading to a premature stop codon at amino acid 313. Individuals carrying only one copy of the mutation are, on average, more muscular than wild-type individuals (p = 7.43 x 10(-6); Kruskal-Wallis Test) and are significantly faster than individuals carrying the wild-type genotype in competitive racing events (Kendall's nonparametric measure, tau = 0.3619; p approximately 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance.

SUBMITTER: Mosher DS 

PROVIDER: S-EPMC1877876 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.

Mosher Dana S DS   Quignon Pascale P   Bustamante Carlos D CD   Sutter Nathan B NB   Mellersh Cathryn S CS   Parker Heidi G HG   Ostrander Elaine A EA  

PLoS genetics 20070430 5


Double muscling is a trait previously described in several mammalian species including cattle and sheep and is caused by mutations in the myostatin (MSTN) gene (previously referred to as GDF8). Here we describe a new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the "bully" whippet. Individuals with this phenotype carry two copies of a two-base-pair deletion in the third exon of MSTN leading to a premature stop codon at amino acid 313. Indivi  ...[more]

Similar Datasets

| S-EPMC8411015 | biostudies-literature
| S-EPMC3962614 | biostudies-literature
| S-EPMC6537384 | biostudies-literature
| S-EPMC4776508 | biostudies-other
| S-EPMC7835227 | biostudies-literature
| S-EPMC2855246 | biostudies-literature
| S-EPMC3930487 | biostudies-literature
| S-EPMC7019314 | biostudies-literature
| S-EPMC9031736 | biostudies-literature
| S-EPMC5679155 | biostudies-literature