Ontology highlight
ABSTRACT:
SUBMITTER: Vikis HG
PROVIDER: S-EPMC18785 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Vikis H G HG Li W W He Z Z Guan K L KL
Proceedings of the National Academy of Sciences of the United States of America 20001101 23
Semaphorin molecules serve as axon guidance signals that regulate the navigation of neuronal growth cones. Semaphorins have also been implicated in other biological processes, including the immune response. Plexins, acting either alone or in complex with neuropilins, have recently been identified as functional semaphorin receptors. However, the mechanisms of signal transduction by plexins remain largely unknown. We have demonstrated a direct interaction between plexin-B1 and activated Rac. Rac s ...[more]