Ontology highlight
ABSTRACT:
SUBMITTER: Mershon SM
PROVIDER: S-EPMC1885232 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Mershon Serena M SM Anding Allyson L AL Chapman Jason S JS Clagett-Dame Margaret M Stonerock Laura A LA Curley Robert W RW
Bioorganic & medicinal chemistry letters 20061025 3
Using solid phase-assisted synthesis and purification, a 49 member library of analogs of the mammary tumor chemopreventive retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been prepared. After prescreening for growth inhibitory activity in human mammary tumor cells (MCF-7) in culture, most of those analogs which showed activity (12 of them) were assayed for apoptosis-inducing activity in the MCF-7 cells. At least 3 of the analogs (13, 24, and 28) showed activity approaching that of 4-HPR. ...[more]