Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa K
PROVIDER: S-EPMC1885445 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Ishikawa Kazuhiro K Ishii Hideshi H Murakumo Yoshiki Y Mimori Koshi K Kobayashi Masahiko M Yamamoto Ken-ichi K Mori Masaki M Nishino Hiroshi H Furukawa Yusuke Y Ichimura Keiichi K
BMC molecular biology 20070521
<h4>Background</h4>Previous studies suggest that human RAD9 (hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulation of the tumor suppressor p53-dependent transactivation of pro-survival P21WAF1. This study examined the exact mechanism of the hRad9 function, especially through the phosphorylation of the C-terminus, in the transcription regulation of P21WAF1.<h4>Results</h4>The tra ...[more]