Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya S
PROVIDER: S-EPMC1885507 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Bhattacharyya Sandip S Brown Diane E DE Brewer Judson A JA Vogt Sherri K SK Muglia Louis J LJ
Blood 20070125 10
To explore the role of glucocorticoids in regulation of kinase pathways during innate immune responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in macrophages (MGRKO). Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) caused greater mortality and cytokine production in MGRKO mice than in controls. Ex vivo, treatment with dexamethasone (Dex) markedly inhibited LPS-mediated induction of inflammatory genes in control but not GR-deficient macro ...[more]