Ontology highlight
ABSTRACT:
SUBMITTER: Mantel C
PROVIDER: S-EPMC1885509 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Mantel Charlie C Guo Ying Y Lee Man Ryul MR Kim Min-Kyoung MK Han Myung-Kwan MK Shibayama Hirohiko H Fukuda Seiji S Yoder Mervin C MC Pelus Louis M LM Kim Kye-Seong KS Broxmeyer Hal E HE
Blood 20070208 10
Karyotypic abnormalities in cultured embryonic stem cells (ESCs), especially near-diploid aneuploidy, are potential obstacles to ESC use in regenerative medicine. Events causing chromosomal abnormalities in ESCs may be related to events in tumor cells causing chromosomal instability (CIN) in human disease. However, the underlying mechanisms are unknown. Using multiparametric permeabilized-cell flow cytometric analysis, we found that the mitotic-spindle checkpoint, which helps maintain chromosoma ...[more]