Ontology highlight
ABSTRACT:
SUBMITTER: Houzet L
PROVIDER: S-EPMC1885669 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Houzet Laurent L Paillart Jean Christophe JC Smagulova Fatima F Maurel Stephan S Morichaud Zakia Z Marquet Roland R Mougel Marylène M
Nucleic acids research 20070410 8
In addition to genomic RNA, HIV-1 particles package cellular and spliced viral RNAs. In order to determine the encapsidation mechanisms of these RNAs, we determined the packaging efficiencies and specificities of genomic RNA, singly and fully spliced HIV mRNAs and different host RNAs species: 7SL RNA, U6 snRNA and GAPDH mRNA using RT-QPCR. Except GAPDH mRNA, all RNAs are selectively encapsidated. Singly spliced RNAs, harboring the Rev-responsible element, and fully spliced viral RNAs, which do n ...[more]