Ontology highlight
ABSTRACT:
SUBMITTER: Parra ZE
PROVIDER: S-EPMC1887558 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Parra Zuly E ZE Baker Michelle L ML Schwarz Ryan S RS Deakin Janine E JE Lindblad-Toh Kerstin K Miller Robert D RD
Proceedings of the National Academy of Sciences of the United States of America 20070529 23
T cells recognize antigens by using T cell receptors (TCRs) encoded by gene segments, called variable (V), diversity (D), and joining (J), that undergo somatic recombination to create diverse binding specificities. Four TCR chains (alpha, beta, gamma, and delta) have been identified to date, and, as T cells develop in the thymus, they express exclusively either an alphabetaTCR or a gammadeltaTCR heterodimer. Here, we show that marsupials have an additional TCR (TCRmu) that has V, D, and J that a ...[more]