Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC1887573 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Huang Jiaying J Smirnov Sergey V SV Lewis-Antes Anita A Balan Murugabaskar M Li Wei W Tang Sheila S Silke Gemma V GV Pütz Mike M MM Smith Geoffrey L GL Kotenko Sergei V SV
Proceedings of the National Academy of Sciences of the United States of America 20070521 23
Type I (IFN-alpha/beta) and type III (IFN-lambdas) IFNs are important components of the host antiviral response. Although type III IFNs possess intrinsic antiviral activity similar to that of type I IFNs, they signal through a specific unique receptor complex, and their functional importance for antiviral resistance is largely uncharacterized. Here, we report the first virus defense mechanism that directly targets type III IFNs. Y136 from Yaba-like disease virus, a yatapoxvirus, is a secreted gl ...[more]