Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC1887608 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Lee Sunyoung S Mandic Jelena J Van Vliet Krystyn J KJ
Proceedings of the National Academy of Sciences of the United States of America 20070529 23
The binding kinetics between cell surface receptors and extracellular biomolecules is critical to all intracellular and intercellular activity. Modeling and prediction of receptor-mediated cell functions are facilitated by measurement of the binding properties on whole cells, ideally indicating the subcellular locations or cytoskeletal associations that may affect the function of bound receptors. This dual need is particularly acute vis à vis ligand engineering and clinical applications of antib ...[more]