Ontology highlight
ABSTRACT:
SUBMITTER: Sachdev P
PROVIDER: S-EPMC1888676 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Sachdev Pallavi P Menon Santosh S Kastner David B DB Chuang Jen-Zen JZ Yeh Ting-Yu TY Conde Cecilia C Caceres Alfredo A Sung Ching-Hwa CH Sakmar Thomas P TP
The EMBO journal 20070510 11
Tctex-1, a light-chain component of the cytoplasmic dynein motor complex, can function independently of dynein to regulate multiple steps in neuronal development. However, how dynein-associated and dynein-free pools of Tctex-1 are maintained in the cell is not known. Tctex-1 was recently identified as a Gbetagamma-binding protein and shown to be identical to the receptor-independent activator of G protein signaling AGS2. We propose a novel role for the interaction of Gbetagamma with Tctex-1 in n ...[more]