Ontology highlight
ABSTRACT:
SUBMITTER: Ihara S
PROVIDER: S-EPMC1888677 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
The EMBO journal 20070510 11
Members of the ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family of secreted proteins play important roles in animal development and pathogenesis. However, the lack of in vivo models has hampered elucidation of the mechanisms by which these enzymes are recruited to specific target tissues and the timing of their activation during development. Using transgenic worms and primary cell cultures, here we show that MIG-17, an ADAMTS family protein required for gonadal leader ...[more]