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Transient loss of high-level mupirocin resistance in Staphylococcus aureus due to MupA polymorphism.

ABSTRACT: Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10(-6)), indicating the transient nature of MupA polymorphism.

SUBMITTER: Driscoll DG

PROVIDER: S-EPMC1891366 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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Transient loss of high-level mupirocin resistance in Staphylococcus aureus due to MupA polymorphism.

Driscoll Daniel G DG Young Casey L CL Ochsner Urs A UA

Antimicrobial agents and chemotherapy 20070416 6

Spontaneous loss of MupA-mediated high-level mupirocin resistance was observed in Staphylococcus aureus, although the isolate gave a PCR-positive test result for mupA. Sequencing of the mupA gene identified a single base-pair deletion that resulted in a frameshift mutation and loss of functional protein. Reversion to the wild-type allele and restoration of high-level resistance occurred with high frequency (>10(-6)), indicating the transient nature of MupA polymorphism. ...[more]

PMID: 17438053

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