Unique maturation program of the IgE response in vivo.
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ABSTRACT:
SUBMITTER: Erazo A
PROVIDER: S-EPMC1892589 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
Unique maturation program of the IgE response in vivo.
Erazo Agustin A Kutchukhidze Nino N Leung Monica M Christ Ana P Guarnieri AP Urban Joseph F JF Curotto de Lafaille Maria A MA Lafaille Juan J JJ
Immunity 20070208 2
A key event in the pathogenesis of asthma and allergies is the production of IgE antibodies. We show here that IgE(+) cells were exceptional because they were largely found outside germinal centers and expressed, from very early on, a genetic program of plasma cells. In spite of their extragerminal center localization, IgE(+) cells showed signs of somatic hypermutation and affinity maturation. We demonstrated that high-affinity IgE(+) cells could be generated through a unique differentiation pro ...[more]
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